College of Arts & Sciences
Cold-raising unmasks sleep disruption in a Drosophila Alzheimer’s disease modelAnanya Nair, Allison J. Yearwood, Brandi N. Besednjak, Mikayla M. Cully, Reece Turner, and Joseph L. BedontChronic sleep loss is a risk factor for Alzheimer's disease (AD), and reduced and fragmented sleep is increasingly appreciated as an early-onset diagnostic and potential therapeutic target for AD. However, robustly modeling AD-like sleep deficits in fruit flies has often been challenging. We report that cold-raising unmasks deficits in sleep duration, fragmentation, and latency in one such model pan-neuronally ...